Mapping Novel Immunogenic Epitopes in IgA Nephropathy
نویسندگان
چکیده
منابع مشابه
Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci.
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide, but its etiologic mechanisms are still poorly understood. Different prevalences among ethnic groups and familial aggregation, together with an increased familial risk, suggest important genetic influences on its pathogenesis. A locus for familial IgAN, called "IGAN1," on chromosome 6q22-23 has been described, without the id...
متن کاملGWAS reveal novel IgA nephropathy risk loci
IgA nephropathy, also known as Berger's disease, is the most common primary glomerulonephritis and a major cause of end stage renal disease (ESRD). IgA nephropathy typically presents as macroscopic haematuria (blood in the urine), often following a mucosal infection, and diagnosis is made based on a renal biopsy which shows deposition of IgA-containing immune complexes in the mesangial area of ...
متن کاملIgA nephropathy.
A great interest in IgA nephropathy was demonstrated in the last few years. Unfortunately, a complete picture of this chronic disease should not yet been made. The article deals with 7 patients with IgA nephropathy treated in our Institute. The following characteristics were examined during a long period of time (1-17 years): clinical picture, course of the disease, clinical and morphologic cor...
متن کامل[IgA nephropathy].
IgA nephropathy is glomerular disease first described in 1968 by Berger, named after him Morbus Berger. The disease is characterized by the presence of IgA dominant or codominant immunoglobulin deposits in glomerular mesangium which can be demonstrated by immunofluorescence. Clinical manifestations of IgA nephropathy in the majority of cases is hematuria which can be macro or microscopic, isola...
متن کاملIgA Nephropathy.
IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international collaborative efforts have led to important discoveries that have improved our understanding of some of the key steps involved in the immunopathogenesis of IgAN. Furthermore, establishment of multicenter networks has contributed to rigorous design and execution of clinical trials that have provided importan...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2014
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.02390314